- Saegertown
- Saint Clair
- Saint Clairsville
- Saint Lawrence
- Saint Marys
- Saint Michael
- Saint Petersburg
- Salisbury
- Salix
- Salladasburg
- Saltillo
- Saltsburg
- Salunga
- Sanatoga
- Sand Hill
- Sandy
- Sandy Lake
- Sandy Ridge
- Sankertown
- Saw Creek
- Saxonburg
- Saxton
- Saylorsburg
- Sayre
- Scalp Level
- Schaefferstown
- Schellsburg
- Schlusser
- Schnecksville
- Schoeneck
- Schubert
- Schuylkill Haven
- Schwenksville
- Scotland
- Scottdale
- Scranton
- Selinsgrove
- Sellersville
- Seltzer
- Seneca
- Seven Fields
- Seven Springs
- Seven Springs
- Seven Valleys
- Seward
- Sewickley
- Sewickley Heights
- Sewickley Hills
- Shade Gap
- Shamokin
- Shamokin Dam
- Shanksville
- Shanor-Northvue
- Sharon
- Sharon Hill
- Sharpsburg
- Sharpsville
- Shartlesville
- Shavertown
- Shawnee Mountain Ski Area
- Sheakleyville
- Sheatown
- Sheffield
- Shelocta
- Shenandoah
- Shenandoah Heights
- Sheppton
- Shickshinny
- Shillington
- Shiloh
- Shiloh
- Shinglehouse
- Shippensburg
- Shippenville
- Shippingport
- Shiremanstown
- Shirleysburg
- Shoemakersville
- Shrewsbury
- Sidman
- Sierra View
- Siglerville
- Silkworth
- Silverdale
- Simpson
- Sinking Spring
- Ski Denton
- Ski Roundtop
- Ski Sawmill
- Skippack
- Skyline View
- Slabtown
- Slatedale
- Slatington
- Slickville
- Sligo
- Slippery Rock
- Slovan
- Smethport
- Smicksburg
- Smithfield
- Smithton
- Smock
- Smoketown
- Sno Mountain
- Snow Shoe
- Snydertown
- Snydertown
- Somerset
- Soudersburg
- Souderton
- South Bethlehem
- South Coatesville
- South Connellsville
- South Fork
- South Greensburg
- South Heights
- South New Castle
- South Park Township
- South Philipsburg
- South Pottstown
- South Renovo
- South Temple
- South Uniontown
- South Waverly
- South Williamsport
- Southmont
- Southview
- Southwest Greensburg
- Spangler
- Spartansburg
- Speers
- Spinnerstown
- Spring City
- Spring Grove
- Spring Hill
- Spring House
- Spring Mills
- Spring Mount
- Spring Mountain Ski Area
- Spring Ridge
- Springboro
- Springdale
- Springfield
- Springmont
- Spry
- Star Junction
- Starbrick
- Starrucca
- State College
- State Line
- Steelton
- Stevens
- Stewartstown
- Stiles
- Stillwater
- Stockdale
- Stockertown
- Stoneboro
- Stonerstown
- Stony Creek Mills
- Stonybrook
- Stormstown
- Stouchsburg
- Stowe
- Stoystown
- Strasburg
- Strattanville
- Strausstown
- Strodes Mills
- Strong
- Stroudsburg
- Sturgeon
- Sugar Grove
- Sugar Notch
- Sugarcreek
- Summerhill
- Summerville
- Summit Hill
- Summit Station
- Sun Valley
- Sun Valley
- Sunbury
- Sunrise Lake
- Susquehanna
- Susquehanna Trails
- Sutersville
- Swarthmore
- Swartzville
- Sweden Valley
- Swissvale
- Swoyersville
- Sykesville
- Sylvania
